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KMID : 0383820150780040401
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Tuberculosis and Respiratory Diseases
2015 Volume.78 No. 4 p.401 ~ p.407
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Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia
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Oh Ji-Hyun
Oh Dong-Jun
Koo So-My
Kim Yang-Ki
Kim Ki-Up
Kim Hyun-Jo
Kim Dong-Won
Uh Soo-Taek
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Abstract
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Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.
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KEYWORD
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Cryptogenic Organizing Pneumonia, Clarithromycin, Macrolides, Adrenal Cortex Hormones
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